Drug Index

Chlorambucil

 
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Mechanism :

Chlorambucil is a bifunctional alkylating agent of the nitrogen mustard type that has been found active against selected human neoplastic diseases.


Indication :

• Hodgkin disease

• Non-Hodgkin lymphoma

• Amyloidosis

• Juvenile idiopathic arthritis


Contraindications :

Chlorambucil should not be used in patients whose disease has demonstrated a prior resistance to the agent. Patients who have demonstrated hypersensitivity to chlorambucil should not be given the drug. There may be cross-hypersensitivity (skin rash) between chlorambucil and other alkylating agents.


Dosing :

0.1-0.2 mg/kg (Oral) daily.

(Safety and efficacy not established, but used off-label).


Adverse Effect :

Bone marrow suppression, nausea and vomiting, diarrhea, oral ulceration, tremors, muscular twitching, confusion, agitation, ataxia, flaccid paresis, hallucinations, urticaria, angioneurotic edema, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, pulmonary fibrosis, hepatotoxicity, jaundice, drug fever, peripheral neuropathy, interstitial pneumonia, sterile cystitis, infertility, leukemia, and secondary malignancies.


Interaction :

There are no known drug interactions with chlorambucil.


07/17/2019 20:35:52 Chlorambucil
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