Drug Index


Mechanism :

Chlorambucil is a bifunctional alkylating agent of the nitrogen mustard type that has been found active against selected human neoplastic diseases.

Indication :

  • Hodgkin disease
  • Non-Hodgkin lymphoma
  • Amyloidosis
  • Juvenile idiopathic arthritis

Contraindications :

Chlorambucil should not be used in patients whose disease has demonstrated a prior resistance to the agent. Patients who have demonstrated hypersensitivity to chlorambucil should not be given the drug. There may be cross-hypersensitivity (skin rash) between chlorambucil and other alkylating agents.

Dosing :

0.1-0.2 mg/kg (Oral) daily.
(Safety and efficacy not established, but used off-label).

Adverse Effect :

Bone marrow suppression, nausea and vomiting, diarrhea, oral ulceration, tremors, muscular twitching, confusion, agitation, ataxia, flaccid paresis, hallucinations, urticaria, angioneurotic edema, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, pulmonary fibrosis, hepatotoxicity, jaundice, drug fever, peripheral neuropathy, interstitial pneumonia, sterile cystitis, infertility, leukemia, and secondary malignancies.

Interaction :

There are no known drug interactions with chlorambucil.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

Chlorambucil is metabolized in the liver. Consider an initial dose reduction.
01/28/2024 15:17:34 Chlorambucil
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