Chlormezanone
Mechanism :
It is a centrally acting muscle relaxant used in the treatment of muscle spasms and musculoskeletal disorders.
Indication :
- Anxiety
- Treatment of muscle spasm.
Contraindications :
Hypersensitivity.
Dosing :
50-100 mg thrice a day PO in children above 5 years of age.
Adverse Effect :
Drowsiness, weakness, nausea, dizziness, abdominal pain, cerebral edema, renal tubular necrosis, hyperglycemia and hypoglycemia, liver damage, encephalopathy, coma and death.
Interaction :
Propoxyphene: May increase side effects such as dizziness, drowsiness, confusion, difficulty concentrating, and other nervous system or mental effects.
Buprenorphine: Cause central nervous system depression such as chlormezanone can lead to serious side effects such as respiratory distress, coma, or even death.
Sodium oxybate: Can increase the effects of drowsiness, confusion, dizziness.
Hepatic Dose :
No dosage guidelines for liver disease available.