Drug Index

Chlorzoxazone

 
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Mechanism :

It is a muscle-relaxant. It acts by inhibiting muscle spasms by acting at the level of the spinal cord and subcortical areas of the brain. It is used as a skeletal muscle relaxant.


Indication :

• Musculoskeletal pain and muscle spasms


Contraindications :

Hypersensitivity, Impaired liver function.


Dosing :

2.5-7.5 mg/kg/dose PO 3-4 times per day. Max: 750 mg/dose.


Adverse Effect :

Light headedness, dizziness, drowsiness, excitement, paradoxical somnolence, malaise, rash angioneurotic edema, gastrointestinal hemorrhage (rare), hepatotoxicity (rare), anaphylaxis (rare).


Interaction :

Doxylamine: Combo may increase risk of CNS depression, psychomotor impairment (additive effects).
Sodium oxybate: May increase risk of CNS depression, psychomotor impairment, adverse effects (additive effects).


07/17/2019 21:11:40 Chlorzoxazone
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