Drug Index

Dacarbazine

 
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Synonym :

DIC

Mechanism :

Dacarbazine is an anti-cancer agent, which acts by different mechanisms i.e. inhibition of DNA synthesis by acting as a purine analog, action as an alkylating agent and interaction with SH groups.


Indication :

• Hodgkin’s disease

• Solid tumors


Contraindications :

Dacarbazine is contraindicated in patients who have demonstrated a hypersensitivity to it in the past and in patients with hepatic and/or renal insufficiency. Dose reduction and close monitoring of hepatic and bone marrow function may be required.


Dosing :

Hodgkin Lymphoma:

150 mg/sqm IV every day for 5 days and to be repeated every 4 weeks OR

375 mg/sqm IV on first day repeated every 15 days.

Neuroblastoma Combination Therapy (off-label):

800-900 mg/sqm IV once on first day and can be repeated after every 3-4 weeks.


Adverse Effect :

Anorexia, nausea, and vomiting, influenza-like syndrome, myalgia, malaise, alopecia, facial flushing, facial paresthesia, significant liver or renal function test, erythematous and urticarial rashes.


Interaction :

Live vaccines: As dacarbazine may impair the immunological responses, administration of live vaccine may lead to the development of a generalized vaccinia.
Phenytoin, Phenobarbitone: May induce dacarbazine metabolism.


07/21/2019 22:20:35 Dacarbazine
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