Drug Index

Fluvoxamine Maleate

Mechanism :

Fluvoxamine is a specific serotonin reuptake inhibition in brain neurons. In fluvoxamine maleate had no significant affinity for histaminergic, alpha or beta adrenergic, muscarinic, or dopaminergic receptors.

Indication :

  • Obsessive compulsive disorder
  • Depression

Contraindications :

Co-administration of thioridazine, terfenadine, astemizole, cisapride, pimozide, alosetron or tizanidine with fluvoxamine maleate is contraindicated. Fluvoxamine maleate tablets are contraindicated in patients with a history of hypersensitivity to fluvoxamine maleate.

Dosing :

Obsessive Compulsive Disorder:
Under 8 years:
Safety and efficacy not established.
8 to 17 years:
Initial immediate release dose: 25 mg orally once a day at bedtime.
Maintenance dose: 25 to 100 mg orally twice a day. The dose may be increased in 25 mg increments every 4 to 7 days, as tolerated, up to a maximum dose of 200 mg per day in children 8-11 years and upto 300 mg in children between 11-17 years.

Adverse Effect :

Nausea, headache, light headedness, restlessness, anxiety, weight loss, seizures, rash, urticaria, fever, neuroleptic malignant syndrome, social disinhibition, euphoria, precipitation of mania, diminished libido, anorgasmia, xerostomia, abnormal ejaculation.

Interaction :

Lithium: There have been reports of both increased and decreased lithium levels.
Benzodiazepines: half-life of concurrently administered diazepam may be prolonged in some patients. Coadministration of alprazolam and fluvoxamine has resulted in increased alprazolam plasma concentrations.
Haloperidol and Clozapine: Elevation of blood levels of haloperidol and clozapine has been observed in patients receiving concomitant fluvoxamine.
Carbamazepine: elevated plasma anticonvulsant concentrations and clinical anticonvulsant toxicity.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-50Dose as in normal renal function
10-30Dose as in normal renal function
<10Dose as in normal renal function but titrate slowly

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxNot dialysed. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Because fluvoxamine is significantly metabolized in the liver, a lower initial dose and a slower increase in dose are advisable.
02/18/2024 16:37:18 Fluvoxamine Maleate
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0