Drug Index

Mitotane

 
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Mechanism :

Mitotane is an adrenolytic agent that suppresses (directly) the adrenal cortex and alters the peripheral metabolism of steroids.


Indication :

• Treatment of inoperable (functional or non-functional) adrenocortical carcinoma

• Off-label: Cushing syndrome


Contraindications :

Hypersensitivity to mitotane or any component of the formulation.


Dosing :

Adrenocortical carcinoma (stage III or IV) (off-label use):

Oral: Initial: 0.5 to 1 g/day divided 3 times a day, increase weekly to a target dose of 4 g/sqm/day (divided 3 times a day) in combination with 8 cycles of the CED regimen (cisplatin, etoposide, and doxorubicin).


Adverse Effect :

Nausea, vomiting, lethargy, anorexia, vertigo, skin rash, diarrhea, weakness, Visual blurring, diplopia, lens opacity, toxic retinopathy, hematuria, hemorrhagic cystitis, albuminuria, hypertension, orthostatic hypotension, flushing, neutropenia, hypothyroidism, growth retardation.


Interaction :

Antihepaciviral Combination Products: CYP3A4 Inducers may decrease the serum concentration of Antihepaciviral Combination Products.

CYP3A4 Substrates: Mitotane may decrease the serum concentration of CYP3A4 Substrates.


07/19/2019 03:01:09 Mitotane
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