Drug Index


Mechanism :

Mitotane is an adrenolytic agent that suppresses (directly) the adrenal cortex and alters the peripheral metabolism of steroids.

Indication :

  • Treatment of inoperable (functional or non-functional) adrenocortical carcinoma
  • Off-label: Cushing syndrome

Contraindications :

Hypersensitivity to mitotane or any component of the formulation.

Dosing :

Adrenocortical carcinoma (stage III or IV) (off-label use):
Oral: Initial: 0.5 to 1 g/day divided 3 times a day, increase weekly to a target dose of 4 g/m²/day (divided 3 times a day) in combination with 8 cycles of the CED regimen (cisplatin, etoposide, and doxorubicin).

Adverse Effect :

Nausea, vomiting, lethargy, anorexia, vertigo, skin rash, diarrhea, weakness, Visual blurring, diplopia, lens opacity, toxic retinopathy, hematuria, hemorrhagic cystitis, albuminuria, hypertension, orthostatic hypotension, flushing, neutropenia, hypothyroidism, growth retardation.

Interaction :

Antihepaciviral Combination Products: CYP3A4 Inducers may decrease the serum concentration of Antihepaciviral Combination Products.

CYP3A4 Substrates: Mitotane may decrease the serum concentration of CYP3A4 Substrates.

Hepatic Dose :

Hepatic impairment may interfere with the metabolism of mitotane and drug accumulation
can occur. No dose adjustments are recommended. Avoid use in patients with severe hepatic impairment. In patients with mild to moderate hepatic impairment, use with caution and monitor liver functions. Adjust dose as per mitotane plasma levels.
03/24/2024 10:37:17 Mitotane
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0