Drug Index

Naltrexone

 
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Mechanism :

It is a pure opioid antagonist which acts as a competitive antagonist at opioid receptor sites, showing the highest affinity for mu receptors.


Indication :

• Crohn Disease (Orphan) in pediatric patients

• Opioid dependence

• Treatment of alcohol use disorder.


Contraindications :

Hypersensitivity to naltrexone or any component of the formulation; opioid dependence or current use of opioid analgesics; acute opioid withdrawal; failure to pass naloxone challenge or positive urine screen for opioids.


Dosing :

Safety and efficacy not established in pediatric patients.

Opioid addiction, Alcohol dependence:≥16 years: 50 mg PO OD.


Adverse Effect :

Injection site reaction, Nausea, headache, anorexia, insomnia, vomiting, diarrhea, dizziness, anxiety, arthralgia, pharyngitis, increased CPK, depression, muscle cramps, back pain, rash, dry mouth, somnolence.


Interaction :

Lofexidine: May decrease the serum concentration of Naltrexone.
Opioid Analgesics: Naltrexone may diminish the therapeutic effect of Opioid Analgesics.


07/17/2019 10:33:19 Naltrexone
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