Drug Index

Mechanism :

It is a pure opioid antagonist which acts as a competitive antagonist at opioid receptor sites, showing the highest affinity for mu receptors.


Indication :

  • Crohn Disease (Orphan) in pediatric patients
  • Opioid dependence
  • Treatment of alcohol use disorder.

Contraindications :

Hypersensitivity to naltrexone or any component of the formulation; opioid dependence or current use of opioid analgesics; acute opioid withdrawal; failure to pass naloxone challenge or positive urine screen for opioids.


Dosing :

Safety and efficacy not established in pediatric patients.
Opioid addiction, Alcohol dependence:
≥16 years
50 mg PO OD.

Adverse Effect :

Injection site reaction, Nausea, headache, anorexia, insomnia, vomiting, diarrhea, dizziness, anxiety, arthralgia, pharyngitis, increased CPK, depression, muscle cramps, back pain, rash, dry mouth, somnolence.


Interaction :

Lofexidine: May decrease the serum concentration of Naltrexone.
Opioid Analgesics: Naltrexone may diminish the therapeutic effect of Opioid Analgesics.



Hepatic Dose :

Use is contraindicated in acute hepatitis or liver failure, severe or acute liver impairment. If AST or ALT > 3 times ULN: monitor closely and adjust dose or withdraw the drug temporarily.
09/28/2020 07:17:05 Naltrexone
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