Drug Index


Mechanism :

Nitrazepam is a benzodiazepine. Benzodiazepines presumably exert their effects by binding at stereo specific receptors at several sites within the central nervous system. All benzodiazepines cause a dose-related central nervous system depressant activity.

Indication :

  • Infantile spasm
  • Myoclonic seizures
  • Periodic epileptic spasms after infancy

Contraindications :

Lorazepam is contraindicated in patients with hypersensitivity to benzodiazepines or to any components of the formulation, in acute narrow-angle glaucoma, pre-existing CNS depression, coma, acute pulmonary insufficiency or sleep apnea. Encephalopathy may be precipitated in patients with severe hepatic insufficiency.

Dosing :

Oral: Initially 0.25 mg/kg every 12 hourly doses followed by maintenance of 0.5 mg/kg every 12 hourly;
Max: 1 mg/kg/day. Total daily dose may be given in 3 divided doses. Achieve target maintenance dose in 2-3 weeks.

Adverse Effect :

The common side effects seen are drowsiness, ataxia, irritability, light-headedness, dysarthria and disinhibition. Occasionally, confusion, hangover, headache, dizziness, blurred vision, depression and hallucinations have been seen. Withdrawal symptoms on long term usage: muscle cramps, tremor, irritability, convulsions and perceptual distortions.

Interaction :

CNS depressants: Anaesthetics, Opioids, Antihistamines, Baclofen, Barbiturates, Antipsychotics, Anxiolytics, Antidepressants: Enhanced effectiveness.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function. Start with small doses

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in GFR<10 mL/min
HDUnlikely to be dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDUnlikely to be dialysed. Dose as in normal renal function

Hepatic Dose :

Mild-to-moderate impairment: There are no dosage adjustments provided in the manufacturer’s labeling; use with caution.
Severe impairment: Use is contraindicated.
03/21/2024 01:32:16 Nitrazepam
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0