Drug Index

Nitrazepam

 
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Mechanism :

Nitrazepam is a benzodiazepine. Benzodiazepines presumably exert their effects by binding at stereo specific receptors at several sites within the central nervous system. All benzodiazepines cause a dose-related central nervous system depressant activity.


Indication :

• Infantile spasm

• Myoclonic seizures

• Periodic epileptic spasms after infancy


Contraindications :

Lorazepam is contraindicated in patients with hypersensitivity to benzodiazepines or to any components of the formulation, in acute narrow-angle glaucoma, pre-existing CNS depression, coma, acute pulmonary insufficiency or sleep apnea. Encephalopathy may be precipitated in patients with severe hepatic insufficiency.


Dosing :

Oral: Initially 0.25 mg/kg every 12 hourly doses followed by maintenance of 0.5 mg/kg every 12 hourly; Max: 1 mg/kg/day. Total daily dose may be given in 3 divided doses. Achieve target maintenance dose in 2-3 weeks.


Adverse Effect :

The common side effects seen are drowsiness, ataxia, irritability, light-headedness, dysarthria and disinhibition. Occasionally, confusion, hangover, headache, dizziness, blurred vision, depression and hallucinations have been seen. Withdrawal symptoms on long term usage: muscle cramps, tremor, irritability, convulsions and perceptual distortions.


Interaction :

CNS depressants: Anaesthetics, Opioids, Antihistamines, Baclofen, Barbiturates, Antipsychotics, Anxiolytics, Antidepressants: Enhanced effectiveness.


07/17/2019 11:21:36 Nitrazepam
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