Ornidazole
Mechanism :
It is an antibiotic similar to metronidazole, but with a longer duration of action. It is used in the treatment of amoebiasis, giardiasis, trichomoniasis and anaerobic infections.
Indication :
- Amoebiasis
- Trichomoniasis
- Giardiasis
- Anaerobic infections
- Trichomonas Vaginilis infections
Contraindications :
Neurological disease, Blood dyscrasias, First trimester of pregnancy, Hypersensitivity, Caution in chronic alcoholics.
Dosing :
40 mg/kg/day twice daily for 2-3 days PO.
Adverse Effect :
GI discomfort, pain in the abdomen, vertigo, headache, skin rash.
Interaction :
Alcohol: Disulfiram like reaction with alcohol.
Phenobarbitone, Rifampin: Reduce its effect.
Warfarin: Lithium toxicity is induced.
Cimetidine: Reduces action of ornidazole.
Hepatic Dose :
Mild or moderate impairment (Child-Pugh class A or B): No dosage adjustment necessary; use with caution and monitor for adverse events
Severe impairment (Child-Pugh class C):
Immediate release tablets, injection: Reduce dose by 50%
Extended release tablets: Use is not recommended.