Drug Index


Mechanism :

It is a benzodiazepine and works by enhancing the effects of a certain natural chemical GABA in the body.

Indication :

  • Anxiety
  • Acute alcohol withdrawal

Contraindications :

It is not recommended for use during pregnancy due to the potential for fetal harm. It may pass into breast milk. Therefore, breast-feeding while using this medication is not recommended.

Dosing :

In children above 12 years, given orally.
Mild-to-moderate anxiety:
10 to 15 mg, thrice daily.
Severe anxiety syndromes:
15 to 30 mg, thrice daily.

Adverse Effect :

Drowsiness, dizziness, blurred vision, or headache may occur. Mental/mood changes, slurred speech, clumsiness, trouble walking, tremor, trouble urinating, sleep disturbances. Fainting, stomach/abdominal pain, persistent nausea, vomiting, fatigue, yellowing eyes or skin, dark urine, persistent sore throat or fever can also occur. Symptoms of a serious allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing.

Interaction :

Sodium Oxybate: Not to be used with sodium oxybate.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Start at low dose and increase according to response

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

No dose adjustment recommended.
01/19/2024 07:21:07 Oxazepam
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