Drug Index

Sertraline

 
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Mechanism :

It is an antidepressant agent used in the treatment of depression in children.


Indication :

• Management of major depressive disorder

• Posttraumatic stress disorder

• Obsessive-compulsive disorder

• Panic disorder with or without agoraphobia

• Premenstrual dysphoric disorder

• Social phobia

• Premature ejaculation

• Vascular headaches


Contraindications :

Hypersensitivity.

Do not use disulfiram concomitantly with oral solution due to alcohol in preparation

Concomitant pimozide: Risk of long QT syndrome.


Dosing :

>6 years: Initially 12.5-25 mg PO 24 hourly increasing slowly as required over several weeks till desired response is seen. Max: 200 mg/day.


Adverse Effect :

Diarrhoea, nausea, headache, insomnia, ejaculation disorder, dizziness, dry mouth, fatigue, somnolence, agitation, anorexia, constipation, dyspepsia and decreased libido.


Interaction :

Linezolid: May increase risk of serotonin syndrome, neuroleptic malignant syndrome.
Pimozide: May increase pimozide levels, risk of QT prolongation, cardiac arrhythmias.
Isocarboxazid: May increase risk of serotonin syndrome, neuroleptic malignant syndrome.


07/18/2019 01:47:53 Sertraline
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