Drug Index

Sodium Phenyl Butyrate

Synonym :

Sodium Phenylbutyrate

Mechanism :

Sodium phenylbutyrate is a metabolically active compound that can serve as alternatives to urea for the excretion of waste nitrogen.

Indication :

  • Hyperammonemia
  • Urea cycle disorders

Contraindications :

Should not be administered to patients with known hypersensitivity, in patients with congestive heart failure or severe renal insufficiency and in clinical states where there is sodium retention with edema.

Dosing :

<20 kg:
450-600 mg/kg/day PO given 3 to 6 times per day.
≥20 kg:
9.9-13 g/m²/day PO given 3 to 6 times per day.

Adverse Effect :

Anorexia, gastrointestinal disturbances, rash, bad taste, taste aversion, body odour, headache, syncope, aplastic anemia, leukopenia, renal tubular acidosis and depression.

Interaction :

Haloperidol, Sodium Valproate and Steroids: Can increase ammonia levels.
Probenecid: Can decrease renal excretion of phenylbutyrate and metabolites.

Hepatic Dose :

No dosage adjustments are recommended.
12/24/2023 07:52:22 Sodium Phenyl Butyrate
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