Drug Index

Tamoxifen

 
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Mechanism :

It is an anti-estrogenic that blocks the actions of estrogens on the estrogen receptors. It is used in the treatment of gynaecomastia and breast cancer.


Indication :

• McCune-Albright Syndrome

• Precocious puberty


Contraindications :

History of blood clots in your veins or your lungs;

If also taking a blood thinner such as warfarin (Coumadin);

Hypersensitivity.


Dosing :

McCune-Albright Syndrome and precocious puberty:

2-10 years: 20 mg once a day. The duration of treatment is up to 12 months.


Adverse Effect :

Vomiting, menstrual irregularities, thrombocytopenia and visual disturbances.


Interaction :

Cimetidine: Cimetidine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Desipramine: Desipramine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Fluconazole: Fluconazole may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Fluconazole is initiated, discontinued or dose changed.
Gemfibrozil: Gemfibrozil may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Gemfibrozil is initiated, discontinued or dose changed.


07/21/2019 21:46:02 Tamoxifen
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