Kernicterus

Eugene L. Mahmoud
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Kernicterus - Investigations
Because of a resurgence of kernicterus during the 1990s, in the United States, studies suggested that hospital discharge of term infants at 24-48 hours of life was a factor. In a pilot study registry monitoring babies with kernicterus, more than 95% of the cases were discharged from the hospital in less than 72 hours. This has prompted closer follow-up with repeat biblirubin determinations, as needed clinically with in 24-48 hours after hospital discharge. Over the last two decades in the United States, national healthcare organizations led by the Academy of Pediatrics, Centers for Disease Control and Prevention (CDC), and the Joint Commission on Accreditation of Healthcare Organizations have alerted practitioners and hospitals about the reemergence of this devastating disorder and provided management guidelines. These practical guidelines can be tailored for effective use in the treatment of hyperbilirubinemia and kernicterus throughout the world. Hispanic and Asian populations appear to have a greater propensity to develop hyperbilirubinemia. However, this does not always translate into the development of kernicterus. Some researchers believe inclusion of the inherited forms of newborn hemolytic disease into the newborn metabolic screen may assist in identifying a newborn at risk for hyperbilirubinemia and kerniciterus, such as glucose- 6- phosphate dehydrogenase deficiency. It is not clear whether knowledge of this condition would change immediate outcomes in the newborn period.


References
Kernicterus Kernicterus 02/13/2016
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