Drug Index

Atomoxetine

 
print
Synonym :

Tomoxetine

Mechanism :

The precise mechanism by which atomoxetine produces its therapeutic effects in Attention-Deficit/Hyperactivity Disorder (ADHD) is unknown but is thought to be related to selective inhibition of the pre-synaptic norepinephrine transporter (Norepinephrine reuptake inhibitor).


Indication :

• ADHD


Contraindications :

Contraindicated in patients known to be hypersensitive to atomoxetine or other constituents of the product.

Should not be taken with an MAOI, or within 2 weeks after discontinuing an MAOI. Treatment with an MAOI should not be initiated within 2 weeks after discontinuing atomoxetine. Its use was associated with an increased risk of mydriasis and therefore its use is not recommended in patients with narrow angle glaucoma.


Dosing :

Initial 0.5 mg/kg/day orally, increase every 3rd day to a target total daily dose of approximately 1.2 mg/kg/day as a single daily dose or as evenly divided doses every 12 hourly. Max: 1.4 mg/kg or 100 mg.


Adverse Effect :

Aggression, irritability, somnolence, vomiting, dyspepsia, fatigue, decreased appetite, dizziness, xerostomia, cough and mood swings.


Interaction :

Albuterol: Should be administered with caution to patients being treated with systemically-administered (oral or intravenous) albuterol (or other beta2 agonists) because the action of albuterol on the cardiovascular system can be potentiated resulting in increases in heart rate and blood pressure.
CYP2D6 inhibitors: Atomoxetine is primarily metabolized by the CYP2D6 pathway to 4-hydroxyatomoxetine. Dosage adjustment may be necessary when coadministered with CYP2D6 inhibitors, e.g., paroxetine, fluoxetine, and quinidine.
Monoamine Oxidase Inhibitors: Should not be taken with an MAOI, or within 2 weeks after discontinuing an MAOI. Treatment with an MAOI should not be initiated within 2 weeks after discontinuing atomoxetine.
Pressor Agents: Because of possible effects on blood pressure, should be used cautiously with pressor agents.


07/14/2019 07:23:54 Atomoxetine
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0