Drug Index


Mechanism :

Bacitracin exerts pronounced antibacterial action in vitro against a variety of gram-positive and a few gram-negative organisms. However, among systemic diseases, only staphylococcal infections qualify for consideration of bacitracin therapy.

Indication :

  • Pneumonia and empyema caused by staphylococci shown to be susceptible to the drug

Contraindications :

This drug is contraindicated in those individuals with a history of previous hypersensitivity or toxic reaction to it.

Dosing :

Infant dose:
For infants under 2500 grams: 900 units/kg/24 hours IM in 2 or 3 divided doses.
For infants over or equal to 2500 grams: 1,000 units/kg/24 hours IM, in 2 or 3 divided doses.
Children: IM 800-1200 units/kg/day divided every 8 hourly.

Adverse Effect :

Albuminuria, cylindruria, azotemia, nausea and vomiting, skin rashes and itching, blood dyscrasias.

Interaction :

Nephrotoxic drugs: Increase toxicity.

Neuromuscular blocking agents and Anesthetic: Increase neuromuscular blockade.

Hepatic Dose :

No dosage adjustments are recommended.
02/14/2024 21:51:41 Bacitracin
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