Drug Index

Cephalexin

Mechanism :

Cephalexin is a semisynthetic cephalosporin antibiotic intended for oral administration. Cephalosporins are bactericidal because of their inhibition of cell-wall synthesis.


Indication :

  • Tonsillitis
  • Pyoderma
  • Pyelonephritis
  • Cystitis
  • Subcutaneous abscess
  • Dental infections
  • Pneumonia

Contraindications :

Cephalexin is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.


Dosing :

Mild infection:
25-50 PO mg/kg/24 hours in 3-4 divided doses for 5-10 days.
Severe infection:
50-100 PO mg/kg/24 hours in 3-4 divided doses for 5-10 days.

Adverse Effect :

Pseudomembranous colitis, dyspepsia, nausea and vomiting, diarrhea, rash, urticaria, angioedema, pruritus, false positive urine glucose test, positive direct Coombs tests.


Interaction :

BCG vaccine, live: Decreases effects of BCG vaccine.
Typhoid vaccine, live: Decreases effects of typhoid vaccine.



Hepatic Dose :

No dosage adjustments are recommended.
01/12/2021 16:20:53 Cephalexin
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