Drug Index


Mechanism :

Cisatracurium Besylate binds to the nicotinic acetylcholine (cholinergic) receptors in the motor endplate and blocks access to the receptors. In the process of binding, the receptor is actually activated - causing a process known as depolarization. Since it is not degraded in the neuromuscular junction, the depolarized membrane remains depolarized and unresponsive to any other impulse, causing muscle paralysis.

Indication :

  • Adjunct to general anaesthesia provide skeletal muscle relaxation.

Contraindications :

Hypersensitivity to cisatracurium (or benzyl alcohol if 10 mL vial is used).

RSI (due to intermediate onset).

Dosing :

Neuromuscular blockade:
1-24 months:
0.15 mg/kg IV over 5-10 seconds during halothane/opioid anaesthesia.
2-12 years:
0.1-0.15 mg/kg IV over 5-15 seconds during halothane/opioid anaesthesia.
IV infusion (During extended surgery):
<2 years:
Safety and efficacy not established.
>2 years:
3 mcg/kg/min post IV bolus (for prevention of rapid spontaneous recovery of NM blockade), followed by 1-2 mcg/kg/min of maintenance dose (dose range of 0.5-10 mcg/kg/min).
Infusion rate to be decreased by 30-40% in case given during stable isoflurane or enflurane anaesthesia.

Adverse Effect :

Histamine release associated bradycardia and bronchospasm, flushing, hypotension, rash.

Interaction :

Aminoglycosides: May potentiate, prolong neuromuscular blockade.

Hepatic Dose :

No dosage adjustments are recommended.
01/19/2024 07:07:11 Cisatracurium
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0