Drug Index

Cyanocobalamin

 
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Synonyms :

Hydroxocobalamin, Mecobalamin, Vit B12, Vitamin B12

Mechanism :

The drug substance is the hydroxylated active form of vitamin B12 and is a large molecule in which a trivalent cobalt ion is coordinated in four positions by a tetrapyrrole ring.


Indication :

• Vitamin B deficiency

• Methylmalonic academia

• Cobalamin utilization disorders

• Homocystinuria-remethylation defects


Contraindications :

Do not give until diagnosis fully established and monitor plasma potassium during initial therapy.


Dosing :

RDA:

0-6 months: 0.4 mcg

7-12 months: 0.5 mcg

1-3 years: 0.9 mcg

4-8 years: 1.2 mcg

9-13 years: 1.8 mcg

>14 years: 2.4 mcg

Pernicious anaemia:

Start: 30-50 mcg SC/IM OD x14 days or give a total dose of 1000 mcg. Maintenance: 100 mcg IM/SC monthly.

Vitamin B12 deficiency: IM/SC

0.2 mcg/kg for 2 days, followed by 1000 mcg/day for the next 2-7 days, this is then followed by 100 mcg/day for 2-7 days, then 100 mcg/week for 1 month. Maintenance dose: 100 mcg IM/SC monthly.


Adverse Effect :

Arthralgia, itching, chills, fever, hot flushes, headache, nausea, vomiting, dizziness and malaise.


Interaction :

No known interactions found.


07/14/2019 06:47:44 Cyanocobalamin
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