Drug Index

Dantrolene Sodium

Mechanism :

Dantrolene is a direct acting skeletal muscle relaxant. It produces relaxation by affecting the contractile response of the muscle at a site beyond the myoneural junction. In skeletal muscle, Dantrolene dissociates excitation-contraction coupling, probably by interfering with the release of Calcium from the sarcoplasmic reticulum by acting on the Ryanodine Receptor Calcium channels.


Indication :

  • Spasticity
  • Malignant Hyperthermia

Contraindications :

Contraindicated in acute muscle spasm, hepatic impairment, cardiovascular or respiratory disease. Dantrolene has been associated with symptomatic hepatitis; liver function tests should be performed before starting treatment and at regular intervals.


Dosing :

Malignant Hyperthermia:
1-3 days prior to surgery:
4-8 mg/kg/day orally in four divided doses
75 minutes prior to anesthesia:
2.5 mg/kg intravenously once over an hour and administer additional doses as per requirement.
Spasticity:
<5 years:
0.5 mg/kg orally OD for 1 week, increase dose weekly to 2 mg/kg orally thrice daily; Max: 100 mg orally every 6 hours.
>5 years:
1 mg/kg/day orally in two divided doses. Max: 12 mg/kg/day orally in 4 divided doses.

Adverse Effect :

Drowsiness, dizziness, weakness, malaise, fatigue, diarrhea, anorexia, nausea, headache and rash. Pulmonary edema, thrombophlebitis and muscle weakness with IV use.


Interaction :

Hepatotoxic Drugs, Calcium-Channel Blockers: Avoid concurrent use of dantrolene.
Metoclopramide: Increases the oral bioavailability of dantrolene.
Neuromuscular Blockers: Potentiate vecuronium-induced neuromuscular block.
Verapamil: May cause hyperkalaemia and myocardial depression.
CNS depressive: Additive CNS depressive effect with other CNS depressants.



Hepatic Dose :

Avoid in active hepatic disease, cirrhosis.
05/17/2021 12:36:02 Dantrolene Sodium
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0