Drug Index


Mechanism :

Metaxalone is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) in the brain.

Indication :

  • Muscle spasm
  • Systemic sclerosis
  • Cardiac allograft rejection

Contraindications :

Hypersensitivity to drug/class/component, Anaemia.

Dosing :

Muscle spasm: 12 years or above: 800 mg orally for 3 to 4 times a day. Give on empty stomach.

Adverse Effect :

Common Reactions: Drowsiness, somnolence, dizziness, headache, nervousness, nausea, vomiting, dyspepsia.

Serious Reactions: Hemolytic anemia, leukopenia, anaphylaxis.

Interaction :

Triprolidine: The CNS depressants, Triprolidine and Metaxalone, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.

Hepatic Dose :

Mild to moderate hepatic impairment: Use with caution. Monitor with serial liver function tests (LFTs).
Severe hepatic impairment: Use is contraindicated.
03/24/2024 10:31:57 Metaxalone
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