Drug Index


Mechanism :

Smooth muscle spasmolytic producing a generalized smooth muscle relaxation including vasodilation, GI sphincter relaxation, bronchiolar muscle relaxation, and potentially a depressed myocardium.

Indication :

  • For intravascular catheter occlusion prophylaxis

Contraindications :

Hypersensitivity to papaverine or any component.

Complete atrioventricular block, Parkinson’s disease.

Dosing :

Safety and efficacy not established in children.
Intra-Arterial dosage:
30 mg of papaverine added to 250 mL of arterial catheter infusion solution (0.9% or 0.45% NaCl with heparin 1 unit/mL) infused continuously at a rate of 1 mL/hour into a peripheral arterial catheter. Generally, avoid use in extremely premature neonates during the immediate period after birth when the risk of developing intracranial hemorrhage is highest.

Adverse Effect :

Tachycardia, BP changes, flushing, dizziness, drowsiness, depression, malaise, sweating, raised intracranial pressure, pruritus, rash, anorexia, diarrhea, constipation, dry mouth, nausea vomiting, priapism.

Interaction :

Serious - Use Alternative:

Sodium oxybate.

Hepatic Dose :

No dosage adjustments are recommended.
02/19/2024 21:27:16 Papaverine
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