Drug Index

Stanozolol

 
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Mechanism :

It is an anabolic steroid with weak androgenic properties used in treatment of hypoplastic anemia and suboptimal growth in children. It has lesser virilizing properties as compared to the androgenic steroids.


Indication :

• Vascular manifestations of Behcet disease

• Hereditary angioedema


Contraindications :

Disease of the Arteries of the Heart, Heart Disease, Liver Problems, Nephrotic Syndrome, Kidney Disease, Enlarged Prostate, Pregnancy, A Mother who is Producing Milk and Breastfeeding, High Amount of Blood Calcium from Spread of Breast Cancer, Breast Cancer in a Male Patient, Cancer of the Prostate Gland, Diabetes, High Cholesterol, High Amount of Calcium in the Blood.


Dosing :

Not used in prepubertal children with open epiphyses.

Adults: 1-10 mg per day PO. Usual range: 0.5-2 mg/day.


Adverse Effect :

Females: Hirsutism, weight gain, menstrual irregularities or postmenopausal bleeding, acne, mood changes.

Males: Oligospermia and decreased ejaculatory volume. Elderly male patients may experience prostatic enlargement resulting in urinary obstruction. Priapism and excessive stimulation may develop.

Children: Androgenic activity associated with anabolic steroids is involved in termination of linear bone growth by closure of the epiphyseal growth centres. Appropriate monitoring of bone age is recommended during stanozolol use in prepubertal patients.

Others: Reduced HDL cholesterol concentrations, raised triglycerides, fluid retention, edema, congestive heart failure, life-threatening peliosis hepatis and hepatic abnormalities including hepatic neoplasms and hepatocellular carcinomas have occurred following prolonged therapy with high doses of anabolic steroids. Oncologic effects following prolonged therapy with large doses of anabolic steroids have included hepatic neoplasms and hepatocellular carcinomas. Alteration in clotting factors II, V, VII and X, prolonged prothrombin time (PT), and increased red cell production, decreased glucose tolerance, osteolytic-induced hypercalcemia, electrolyte balance, nitrogen retention, and urinary calcium excretion, decrease levels of thyroxin-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4, nausea and vomiting.


Interaction :

An anticoagulant (blood thinner) such as Warfarin (Coumarin);

Insulin or an oral diabetes medicine such as Glipizide (Glucotrol), Glyburide (Diabeta, Glynase, Micronase), Glimepiride (Amaryl), Chlorpropamide (Diabinese), Acetohexamide (Dymelor), Tolbutamide (Orinase), Tolazamide (Tolinase), and others.


07/14/2019 14:39:11 Stanozolol
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