Drug Index

Teicoplanin

 
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Mechanism :

It is an antibiotic that acts against coagulase producing Gram-positive cocci. It is used in the treatment of endocarditis, peritonitis, septicemia, osteoarthritis.


Indication :

• Severe Gram-positive infections


Contraindications :

Hypersensitivity.


Dosing :

Initial: 10 mg/kg/dose every 12 hours for 3 doses IV and then 6 mg/kg/day IV/IM 24 hourly.

Neonates: Initial dose is 16 mg/kg and maintenance dose is 8 mg/kg/day IV. Infuse over 30 mins.


Adverse Effect :

Fever, chills, allergic reactions, GI disturbances, headache, dizziness, “red-man” syndrome, disturbances in liver enzymes, renal impairment, ototoxicity, blood dyscrasias, erythema and thrombophlebitis at site of administration.

Rare: Stevens-Johnson syndrome, toxic epidermal necrolysis.


Interaction :

Other nephrotoxic and/or neurotoxic drugs.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Give normal loading dose, then dose as in normal renal function
10-20Give normal loading dose, then 200–400 mg every 24–48 hours
<10Give normal loading dose, then 200–400 mg every 48–72 hours

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxDialysed. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in GFR=10–20 mL/min

Hepatic Dose :

No dosage adjustments are recommended.
04/11/2020 15:08:24 Teicoplanin
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