Drug Index

Triclofos

 
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Mechanism :

Triclofos is a melatonin agonist. Sleep inducing, anxiolytic and analgesic effects have been reported. It is devoid of addictive and withdrawal effects. Not developed as an analgesic.


Indication :

• Procedures- to reduce pain

• Sedation for night


Contraindications :

Contraindicated in patients with marked hepatic or renal impairment and in patients with severe cardiac disease. Oral dosage forms of chloral hydrate are contraindicated in the presence of gastritis. Also contraindicated in patients who have previously exhibited a hypersensitivity to the drug.


Dosing :

30-50 mg/kg as single dose, orally. Doses upto 100 mg/kg used for level 4 sedation before doing procedures.


Adverse Effect :

Occasionally patients become somnambulistic, disoriented and incoherent and show paranoid behaviour. Rarely, excitement, tolerance, addiction, delirium, drowsiness, staggering gait, ataxia, light headedness, vertigo, dizziness, nightmares, malaise, mental confusion and hallucinations have been reported. Others: leukopenia and eosinophilia, allergic skin rashes including hives, erythema, eczematoid dermatitis, urticaria, and scarlatiniform exanthemas, gastric irritation and occasionally nausea and vomiting, flatulence, diarrhea, and unpleasant taste occur.


Interaction :

Oral Anticoagulants: May cause hypoprothrombinemic effects
Intravenous Furosemide: Sweating, hot flashes, and variable blood pressure including hypertension.
CNS Depressants such as Alcohol Barbiturates and Tranquilizers: Additive in effect and the dosage should be reduced when such combinations are given concurrently.


07/17/2019 10:57:10 Triclofos
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