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Question :

Posted On : 07 Oct 2021

Is the single dose of live Hepatitis A Vaccine (Biovac A) better in respect to the seroconversion and prolong protection than the two-dose schedule of inactivated hepatitis A vaccine.

Expert Answer :

Answer Discussion :

L

lenard kandapo

0

yes it may be better

3 years ago

L

Liliia Demianenko

0

Live vaccine is better I think

3 years ago

D

Dr. Sandeep Raina

0

yes
single dose is better

3 years ago

K

KRITI AGRAWAL

0

2 doses of inactivated are better

3 years ago

S

SHASHANK KUMAR

0

yes i think so

3 years ago

Answer 1

The inactivated Hep A vaccine is FDA approved and in use all over the world with proven efficacy in a prime-boost schedule. In the present-day immunization program, we have started recommending 2 doses even for live vaccines like Measles, MMR, Varicella, etc. Hence the IAP Committee on Immunization felt the even for Live Hep A vaccine 2 doses may be ideal. recent multicentric trials on BioVac A had concluded that a single dose is highly immunogenic but how long the protection lasts is a question mark, since long-term follow-up results of infants who received a single dose are yet to be tabulated in the Indian context.
However in private practice where the risk of breakthrough infection can not be predicted it is better to adapt 2 dose schedule in my opinion

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