Drug Index

Carbamylglutamate

Mechanism :

N-carbamylglutamate (NCG), an analogue of endogenous N-acetylglutamate which is an activator of arginine synthesis.


Indication :

  • N-acetyl glutamate synthase (NAGS) deficiency
  • Carbamoyl phosphate synthase deficiency

Contraindications :

No significant contraindications found.


Dosing :

Oral:
12.5-25 mg/kg/dose QDS.

Adverse Effect :

Chinese restaurant syndrome characterized as a sympathomimetic reaction including tachycardia, profuse sweating, increased bronchial secretion and temperature, and persistent crying.


Interaction :

No significant interactions found.



Hepatic Dose :

No dosage adjustments are recommended.
03/29/2021 21:40:49 Carbamylglutamate
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