Carbamylglutamate
Mechanism :
N-carbamylglutamate (NCG), an analogue of endogenous N-acetylglutamate which is an activator of arginine synthesis.
Indication :
- N-acetyl glutamate synthase (NAGS) deficiency
- Carbamoyl phosphate synthase deficiency
Contraindications :
No significant contraindications found.
Dosing :
Oral:
12.5-25 mg/kg/dose QDS.
Adverse Effect :
Chinese restaurant syndrome characterized as a sympathomimetic reaction including tachycardia, profuse sweating, increased bronchial secretion and temperature, and persistent crying.
Interaction :
No significant interactions found.
Hepatic Dose :
No dosage adjustments are recommended.