Drug Index


Mechanism :

Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamine's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown.

Indication :

  • Seasonal and perennial allergic rhinitis
  • Vasomotor rhinitis
  • Allergic conjunctivitis
  • Urticaria and angioedema.

Contraindications :

Hypersensitivity, Severe hypertension or Coronary artery disease, MAO inhibitor therapy, GI or GU obstruction, narrow angle glaucoma.

Dosing :

Oral. Dose according to pseudo ephedrine component: 4 mg/kg/day or the carbinoxamine component:
0.2-0.4 mg/kg/day.

Adverse Effect :

Anaphylaxis/anaphylactoid reaction, hemolytic anemia, thrombocytopenia, agranulocytosis, pancytopenia, leukopenia, arrhythmias, seizures, toxic psychosis, labyrinthitis, acute neuritis.

Interaction :

Potassium derivates: May delay solid potassium passage through GI tract.
Doxylamine: Combination may increase risk of CNS depression.
Anticholinergic agents: May further delay gastric emptying.

Hepatic Dose :

No dosage adjustments are recommended.
03/20/2024 23:46:01 Carbinoxamine
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