Drug Index

Carbinoxamine

 
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Mechanism :

Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamine's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown.


Indication :

• Seasonal and perennial allergic rhinitis

• Vasomotor rhinitis

• Allergic conjunctivitis

• Urticaria and angioedema.


Contraindications :

Hypersensitivity, Severe hypertension or Coronary artery disease, MAO inhibitor therapy, GI or GU obstruction, narrow angle glaucoma.


Dosing :

Oral. Dose according to pseudo ephedrine component: 4 mg/kg/day or the carbinoxamine component: 0.2-0.4 mg/kg/day.


Adverse Effect :

Anaphylaxis/anaphylactoid reaction, hemolytic anemia, thrombocytopenia, agranulocytosis, pancytopenia, leukopenia, arrhythmias, seizures, toxic psychosis, labyrinthitis, acute neuritis.


Interaction :

Potassium derivates: May delay solid potassium passage through GI tract.
Doxylamine: Combination may increase risk of CNS depression.
Anticholinergic agents: May further delay gastric emptying.


07/18/2019 09:17:19 Carbinoxamine
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