Drug Index

Carisoprodol

 
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Mechanism :

Carisoprodol is a central nervous system depressant that acts as a sedative and skeletal muscle relaxant. Rather than acting directly on skeletal muscle, carisoprodol interrupts neuronal communication within the reticular formation and spinal cord, resulting in sedation and alteration in pain perception. Its exact mechanism of action is not yet known.


Indication :

• For the relief of discomfort associated with acute, painful, musculoskeletal conditions.


Contraindications :

Hypersensitivity to carisoprodol, meprobamate, mebutamate, tybamate.

History of acute intermittent porphyria.


Dosing :

<16 years: Not recommended.

>16 years: 250-350 mg PO every 8 hours and bed time.


Adverse Effect :

Drowsiness, dizziness, headache, orthostatic hypotension, syncope, tachycardia, agitation, pruritus, rash.


Interaction :

Clopidogrel: May increase carisoprodol levels, risk of adverse effects.
Doxylamine: May increase risk of CNS depression, psychomotor impairment.
Sodium oxybate: May increase risk of CNS depression, psychomotor impairment, adverse effects.
Ticlopidine: May increase carisoprodol levels, risk of adverse effects.


07/15/2019 05:58:50 Carisoprodol
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