Drug Index

Chlorpheniramine Maleate

 
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Synonym :

Dexchlorpheniramine

Mechanism :

Chlorpheniramine is an anti-histaminic. It competes with histamine for H1-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract.


Indication :

• Allergy

• Anaphylaxis

• Urticaria


Contraindications :

Hypersensitivity to chlorpheniramine or any component of the formulation, narrow-angle glaucoma, bladder neck obstruction, symptomatic prostate hypertrophy, during acute asthmatic attacks, stenosing peptic ulcer, pyloroduodenal obstruction. Avoid use in premature and term new-borns due to possible association with SIDS.


Dosing :

Oral:

<2 years: Safety and efficacy not established.

2-6 years: 1 mg 4-6 hourly, maximum 6 mg.

6-12 years: 2 mg 3-4 times, maximum 12 mg.

>12 years: 4 mg 4-6 hourly, maximum 24 mg.

IM/IV/SC:

<1 year: 250 mcg/kg.

1-5 years: 2.5-5 mg.

6-12 years: 5-10 mg.

12-18 years: 10-20 mg OD.

Repeat up to 4 times daily, Max: 49 mg in adults.


Adverse Effect :

Drowsiness, headache, excitability, fatigue, nervousness, dizziness, nausea, xerostomia, diarrhea, abdominal pain, appetite increase, weight gain, urinary retention, arthralgia, weakness, diplopia, polyuria, thickening of bronchial secretions


Interaction :

CNS Depressants, MAO Inhibitors, Tricyclic Antidepressants, Phenothiazines: Increased toxicity.
Azole Antifungals, Ciprofloxacin, Clarithromycin, Diclofenac, Doxycycline, Erythromycin, Imatinib, Isoniazid, Nefazodone, Nicardipine, Propofol, Protease Inhibitors, Quinidine, and Verapamil: May increase the levels/effects of chlorpheniramine.


07/17/2019 10:26:46 Chlorpheniramine Maleate
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