Drug Index


Mechanism :

Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity.

Indication :

  • Allergic rhinitis
  • Urticaria

Contraindications :

Contraindicated in patients who are hypersensitive to this medication or to any of its ingredients, or to loratadine.

Dosing :

Under 6 months:
Safety and efficacy not established.
6-12 months:
1 mg; orally once daily.
1-5 years:
1.25 mg; orally once daily.
6-11 years:
2.5 mg; orally once daily.
12-18 years:
5 mg orally once daily.

Adverse Effect :

Tachycardia, edema, somnolence, fatigue, dizziness, nausea, elevated liver enzymes.

Interaction :

Additive CNS depressant: effect with other CNS depressants and alcohol.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnlikely to be dialysed. Dose as in normal renal function

Hepatic Dose :

Dosage interval adjustment may be necessary and dose intervals may have to be increased.
02/18/2024 17:24:01 Desloratadine
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