Drug Index

Lorazepam

 
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Mechanism :

Lorazepam is a benzodiazepine. Benzodiazepines presumably exert their effects by binding at stereo specific receptors at several sites within the central nervous system. All benzodiazepines cause a dose-related central nervous system depressant activity.


Indication :

• Anxiety

• Psychosomatic Disorders

• Premedication

• Insomnia due to anxiety

• Acute panic attacks

• Status epilepticus


Contraindications :

Lorazepam is contraindicated in patients with hypersensitivity to benzodiazepines or to any components of the formulation, in acute narrow-angle glaucoma, pre-existing CNS depression, coma, acute pulmonary insufficiency or sleep apnea. Encephalopathy may be precipitated in patients with severe hepatic insufficiency.


Dosing :

Anxiety/sedation:

Children: 0.05-0.1 mg/kg/dose orally 4-8 hourly. Max: 2 mg/dose.

Status epilepticus:

Children: 0.05-0.1 mg/kg over 2-5 min and if required repeat every 10-15 min as needed. Max dose: 4 mg OR,

0.1 mg/kg at slow IV, max rate of 2 mg/min. Max dose: 4 mg.

Adolescent: 4 mg slow IV, if seizure persists may repeat after 10-15 min.


Adverse Effect :

The common side effects seen are drowsiness, ataxia, irritability, light-headedness, dysarthria and disinhibition. Occasionally, confusion, hangover, headache, dizziness, blurred vision, depression and hallucinations have been seen. Withdrawal symptoms on long term usage: Muscle cramps, tremor, irritability, convulsions and perceptual distortions.


Interaction :

CNS depressants - Anaesthetics, Opioids, Antihistamines, Baclofen, Barbiturates, Antipsychotics, Anxiolytics, Antidepressants: Enhanced effectiveness.


07/21/2019 21:46:31 Lorazepam
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