Drug Index


Mechanism :

Methocarbamol is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain.
Methocarbamol is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

Indication :

  • Treatment of tetanus
  • Muscle Spasms

Contraindications :

Renal impairment (IM or IV use), Seizure disorder (IM or IV use).

Caution if hypersensitivity. to latex (INJ form)

Dosing :

IV: 500 mg/m²/dose IV every 6 hours, as and when needed. Max: 1800 mg/m²/day for <3 days. Alternatively: 15 mg/kg IV every 6 hours, as and when needed.
Muscle spasm (Only for adults):
1500 mg orally, every 6 hours for 48-72 hours, then decrease to 4-4.5 g/day in 3-6 divided doses. Max: 8 g/day.

Adverse Effect :

Common Reactions: Dizziness, somnolence, light-headedness, nausea, urticaria, pruritus, rash, conjunctivitis, blurred vision, headache, fever, flushing, hypotension, metallic taste, nasal congestion.

With injectable: Syncope, bradycardia, hypotension, drowsiness, bad taste in the mouth, thrombophlebitis, injection site pain.

Serious reactions: Seizures, hypotension, syncope, bradycardia, extravasation/tissue damage, angioedema, anaphylactoid reaction, leukopenia.

Interaction :

Triprolidine: The CNS depressants, Triprolidine and Methocarbamol, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.

Hepatic Dose :

In patients with chronic liver disease, the elimination half-life may be prolonged. Therefore, dose interval may be increased.
03/20/2024 22:31:26 Methocarbamol
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