Drug Index


Mechanism :

Tolperisone (HCl) is a centrally acting muscle relaxant. Tolperisone (HCl) is used in the symptomatic treatment of spasticity and muscle spasm.

Indication :

  • Acute or chronic treatment of pathologically elevated skeletal muscle tone in organic neurological disorders.
  • Treatment of muscular hypertonicity and muscle spasms associated with locomotor diseases (e.g. spondylosis, spondylarthrosis, cervical and lumbar syndromes, arthrosis of large joints).
  • Rehabilitation after orthopaedic and trauma surgery.
  • Treatment of obliterative vascular diseases as well as syndromes due to impaired vascular innervation (e.g. acrocyanosis, dysbasia angioneurotic intermittent).

Contraindications :

Tolperisone (HCl) is contraindicated in conditions like Myasthenia gravis.

Dosing :

<6 years:
5 mg/kg daily orally divided in three doses.
6-14 years:
2-4 mg/kg daily orally, divided in three doses.
150-450 mg orally daily divided in 3 doses.

Adverse Effect :

Muscle weakness, somnolence, hypersensitivity, urticaria, pruritus, dyspnoea, angioedema, erythema, rash and anaphylactic reaction/anaphylactic shock, hyperhidrosis.

Interaction :

No interactions.

Hepatic Dose :

Individual titration with close monitoring of the patient’s condition and hepatic function is recommended in patients with moderate hepatic impairment. Use of tolperisone is not recommended in patients with severe hepatic impairment.
02/13/2024 15:03:52 Tolperisone
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0