Drug Index

Cinnarizine

 
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Mechanism :

Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. Cinnarizine has also been implicated in binding to dopamine D2 receptors, histamine H1 receptors, and muscarinic acetylcholine receptors.


Indication :

• Vertigo/Meniere’s disease

• Motion sickness


Contraindications :

Hypersensitivity to cinnarizine

Children <5 years of age


Dosing :

Use in children 5-12 years.

Vertigo: 15 mg 3 times a day PO.

Motion sickness:15 mg oral 2 hours before travel and then 7.5 mg PO every 8 hours during the journey.


Adverse Effect :

Somnolence, indigestion, headache, dry mouth, increased sweating, weight gain, mouth sores, rash, jaundice, tremors, restlessness.


Interaction :

No significant interactions found.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDUnlikely to be dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnlikely to be dialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
05/21/2020 03:32:08 Cinnarizine
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