Drug Index

Cinnarizine

 
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Mechanism :

Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. Cinnarizine has also been implicated in binding to dopamine D2 receptors, histamine H1 receptors, and muscarinic acetylcholine receptors.


Indication :

• Vertigo/Meniere’s disease

• Motion sickness


Contraindications :

Hypersensitivity to cinnarizine

Children <5 years of age


Dosing :

Use in children 5-12 years.

Vertigo: 15 mg 3 times a day PO.

Motion sickness:15 mg oral 2 hours before travel and then 7.5 mg PO every 8 hours during the journey.


Adverse Effect :

Somnolence, indigestion, headache, dry mouth, increased sweating, weight gain, mouth sores, rash, jaundice, tremors, restlessness.


Interaction :

No significant interactions found.


07/13/2019 01:17:40 Cinnarizine
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