Drug Index

Methdilazine

 
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Mechanism :

It is an antihistaminic agent with moderate sedative properties. It also has antimuscarinic action.


Indication :

• It is used in allergic conditions such as urticaria, angioedema, rhinitis and conjunctivitis.


Dosing :

0.3 mg/kg/dose 6-8 hourly PO/IV.


Adverse Effect :

GI disturbances, headache, sedation, dizziness.


Interaction :

Bromocriptine: The phenothiazine decreases the effect of bromocriptine.
Cisapride: Increased risk of cardiotoxicity and arrhythmias.
Dexfenfluramine: Decreased anorexic effect, may increase psychotic symptoms.
Diethylpropion: Decreased anorexic effect, may increase psychotic symptoms.
Donepezil: Possible antagonism of action.
Fenfluramine: Decreased anorexic effect, may increase psychotic symptoms.
Galantamine: Possible antagonism of action.
Guanethidine: Methdilazine may decrease the effect of guanethidine.
Mazindol: Decreased anorexic effect, may increase psychotic symptoms.
Phentermine: Decreased anorexic effect, may increase psychotic symptoms.
Phenylpropanolamine: Decreased anorexic effect, may increase psychotic symptoms.
Terfenadine: Increased risk of cardiotoxicity and arrhythmias.


07/14/2019 06:58:24 Methdilazine
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