Drug Index

Clobazam

 
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Mechanism :

Clobazam is a benzodiazepine derivative. It is an anxiolytic and an anticonvulsant.


Indication :

• Absence seizure

• Tonic and clonic seizure

• Atonic seizure

• Myoclonic seizure

• Partial seizure

• Catamenial (menstruation) seizures

• Cluster seizure


Contraindications :

Acute severe respiratory insufficiency, alcohol or drug dependence, myasthenia gravis, sleep apnea, hepatic dysfunction. Dose adjustment is required in hepatic and renal impairment.


Dosing :

<12 years: Initially oral 125 microgram/kg/dose BDS, followed by 250 microgram/dose, Max: 500 microgram/dose in 2 doses.

12-18 years: 10 mg/dose 2 times daily followed by maintenance doses 10-15 mg/dose, Max: 30 mg/dose in 2 doses.


Adverse Effect :

Somnolence, pyrexia, tachyphylaxis, behaviour disturbance and cognitive dysfunction.


Interaction :

Antiepileptics: May alter plasma levels of other antiepileptics.
Cimetidine: May enhance the effects.
Rifampicin: May reduce the effects of clobazam.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function. Start with low doses

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnlikely to be dialysed. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Mild to moderate hepatic impairment
> 30 kg: Start with 5 mg PO OD and increase to 5 mg PO BD after one week, 10 mg PO BD after 2 weeks and then 20 mg PO BD at the end of 3 weeks if clinically indicated.
< 30kg: Start with 5 mg PO OD and increase to 5 mg PO BD after two weeks, 10 mg PO BD after 3 weeks if clinically indicated.
Severe hepatic impairment
Dosing data not available.
07/29/2020 10:28:06 Clobazam
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