Ebastine
Mechanism :
Ebastine, a piperidine derivative, is a long-acting, nonsedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H1 receptors. It is metabolised to active metabolite, carebastine. It has antihistaminic, antiallergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or antimuscarinic actions.
Indication :
- Allergic rhinitis
- Chronic urticaria
Contraindications :
Hypersensitivity & Cardiac arrhythmias.
Caution is advised when used in hepatic impairment, renal insufficiency, QTc interval prolongation.
Dosing :
Oral
Adults:
10-20 mg once daily.
Child >6 years:
5 mg once daily.
Adverse Effect :
Headache, dry mouth, inflammation of pharynx/nose/sinus, drowsiness, indigestion, abdominal pain, nosebleed, weakness, nausea and sleeplessness.
Interaction :
Ketoconazole, Itraconazole, Clarithromycin or Erythromycin: Concomitant use of ketoconazole, itraconazole, clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation.
Hepatic Dose :
Mild to moderate hepatic impairment: no dose adjustment is necessary for treatment up to 7 days.
Severe hepatic impairment: Dose reduction may be required.