Drug Index


Mechanism :

Ebastine, a piperidine derivative, is a long-acting, nonsedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H1 receptors. It is metabolised to active metabolite, carebastine. It has antihistaminic, antiallergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or antimuscarinic actions.

Indication :

  • Allergic rhinitis
  • Chronic urticaria

Contraindications :

Hypersensitivity & Cardiac arrhythmias.

Caution is advised when used in hepatic impairment, renal insufficiency, QTc interval prolongation.

Dosing :

10-20 mg once daily.
Child >6 years:
5 mg once daily.

Adverse Effect :

Headache, dry mouth, inflammation of pharynx/nose/sinus, drowsiness, indigestion, abdominal pain, nosebleed, weakness, nausea and sleeplessness.

Interaction :

Ketoconazole, Itraconazole, Clarithromycin or Erythromycin: Concomitant use of ketoconazole, itraconazole, clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation.

Hepatic Dose :

Mild to moderate hepatic impairment: no dose adjustment is necessary for treatment up to 7 days.
Severe hepatic impairment: Dose reduction may be required.
02/16/2024 17:28:11 Ebastine
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