Drug Index


Mechanism :

It is an anticholinesterase agent used as a muscle-relaxant. It is used in the diagnosis and treatment of myasthenia gravis. It is used in combination with other drugs to relieve intra-ocular pressure encountered in glaucoma. It is the antidote used for atropine poisoning.

Indication :

  • For the treatment of glaucoma
  • Treatment of severe anticholinergic toxicity.

Contraindications :

Hypersensitive to sulfites, GI obstruction, GU tract obstruction, Asthma, Gangrene, Diabetes mellitus, Severe cardiovascular disease, Arrhythmias, Glaucoma, angle-closure, Neonates.

Dosing :

Anticholinergic drug overdosage:
Initially 0.02 mg/kg/dose IV over 1 min. Maybe repeated at 5-10 min interval if required. Maximum dose: 0.5 mg/min and cumulative dose: 2 mg.

Adverse Effect :

Cholinergic crisis, seizures, tremor, fasciculation, bronchoconstriction, bradycardia, diaphoresis, hallucinations, hypotension and vomiting.

Interaction :

Avoid/Use Alternative:
Bethanechol, Cevimeline, Pilocarpine, Succinylcholine.

Hepatic Dose :

No dose adjustment recommended.
02/18/2024 18:17:41 Physostigmine
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