Toxic Shock Syndrome

Neha Bansal
What are the Signs and Symptoms of Toxic Shock Syndrome?
The case definition requires all 3 manifestations of fever, hypotension and diffuse scarlatiniform rash (erythema, which blanches and desquamates one or two weeks after onset of illness). It presents with various signs of infection, hemodynamic dysfunction and organ failure. (2)

As per CDC (1), there should be involvement of more than 3 extra-cutaneous organs for a diagnosis. These include
- gastrointestinal (vomiting or diarrhea at onset of illness),
- muscular (severe myalgia or creatine phosphokinase level >2 times upper normal limit),
- mucous membrane (vaginal, oropharyngeal or conjunctival hyperemia),
- renal (blood urea nitrogen or creatinine levels > 2 times upper normal limit or > 5 leukocytes per high-power field-in the absence of a urinary tract infection),
- hepatic (total bilirubin, serum asparate aminotransferase or serum alanine aminotransferase levels >2 times upper normal limit),
- hematologic (platelets < 100,000 per cumm),
- central nervous system (disorientation or alterations in consciousness without focal neurological signs when fever and hypotension are absent).

Toxic Shock Syndrome Toxic Shock Syndrome 01/23/2013
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