Zika Virus: an Emerging Global Pandemic

Monica Madvariya
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Zika Virus - Differential Diagnosis
The differential diagnosis for Zika virus infection, based on its clinical features, is broad. In addition to dengue, other considerations include leptospirosis, malaria, rickettsia, group A streptococcus, rubella, measles, and parvovirus, enterovirus, adenovirus, and alphavirus infections (e.g.,Chikungunya, Mayaro, Ross River, Barmah Forest, O'nyong-nyong, and Sindbis viruses)."[26]

The diagnostic tests for Zika virus are not as yet available in India. In the Americas and other endemic countries, Zika virus is diagnosed through PCR (polymerase chain reaction) and virus isolation from blood samples. However, the period of viremia can be short and it is recommended that RT-PCR testing be done on serum collected within 1 to 3 days of symptom onset or on saliva or urine samples collected during the first 3 to 5 days.[27]
Diagnosis by serology is unreliable due to cross reacting antibodies with other flaviviruses such as dengue, West Nile and yellow fever.


References
Zika Virus: an Emerging Global Pandemic Zika Virus: an Emerging Global Pandemic 02/10/2016
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