Drug Index

Cetirizine

 
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Mechanism :

Cetirizine is an orally active and selective second generation H1-receptor antagonist. Cetirizine, a metabolite of hydroxyzine, is an antihistamine; its principal effects are mediated via selective inhibition of peripheral H1 receptors. It also possesses some mast cell stabilizing properties.


Indication :

• Allergic rhinitis

• Hay fever

• Urticaria


Contraindications :

Cetirizine is contraindicated in those patients with a known hypersensitivity to it or any of its ingredients or hydroxyzine.


Dosing :

6-11 months: 2.5 mg PO OD.

1-6 years: 2.5 mg PO once or twice a day.

6-18 years: 5-10 mg (Oral) daily; maximum: 10 mg/day.


Adverse Effect :

Somnolence, headache, dizziness, dry mouth.


Interaction :

No clinically significant drug interactions have been found with theophylline at a low dose, azithromycin, pseudoephedrine, ketoconazole, or erythromycin. There was a small decrease in the clearance of cetirizine with larger theophylline doses.


07/21/2019 22:33:33 Cetirizine
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