Chlorazepate
Mechanism :
It is a benzodiazepine group of drug used in the treatment of panic disorders and anxiety states.
Indication :
- Anxiety disorders
- Adjunctive therapy in the management of partial seizures
- Symptomatic relief of acute alcohol withdrawal.
Contraindications :
Documented hypersensitivity, Breastfeeding, Narrow-angle glaucoma.
Dosing :
9-12 years:
3.75-7.5 mg/dose PO bd.
>12 years:
7.5 mg/dose PO 2-3 times daily.
Adverse Effect :
Drowsiness, confusion, depression, blurred vision.
Interaction :
1. with sodium oxybate: may increase risk of CNS and resp. depression, other adverse effects
2. with clarithromycin: may incr. benzodiazepine levels, risk of CNS depression, psychomotor impairment
3. with doxylamine: may increase risk of CNS depression, psychomotor impairment
4. with chloramphenicol: may increase benzodiazepine levels, risk of CNS depression, psychomotor impairment
Hepatic Dose :
Dose may have to be reduced or dosing interval may have to be increased due to impaired hepatic metabolism. Specific guidelines for dosage adjustment are not available.