Drug Index

Chlorazepate

 
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Mechanism :

It is a benzodiazepine group of drug used in the treatment of panic disorders and anxiety states.

Indication :

• Anxiety disorders

• Adjunctive therapy in the management of partial seizures

• Symptomatic relief of acute alcohol withdrawal.


Contraindications :

Documented hypersensitivity, Breastfeeding, Narrow-angle glaucoma.


Dosing :

9-12 years: 3.75-7.5 mg/dose PO bd.

>12 years: 7.5 mg/dose PO 2-3 times daily.


Adverse Effect :

Drowsiness, confusion, depression, blurred vision.


Interaction :

1. with sodium oxybate: may increase risk of CNS and resp. depression, other adverse effects 2. with clarithromycin: may incr. benzodiazepine levels, risk of CNS depression, psychomotor impairment 3. with doxylamine: may increase risk of CNS depression, psychomotor impairment 4. with chloramphenicol: may increase benzodiazepine levels, risk of CNS depression, psychomotor impairment
07/19/2019 03:04:26 Chlorazepate
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