Hand, Foot and Mouth Disease

Nikhil Thatte
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Hand, Foot and Mouth Disease - Differential Diagnosis
Herpangina, Herpetic gingivostomatitis, Aphthous stomatitis, Stevens-Johnson's syndrome are some of the conditions which need to be differentiated from HMFD.

Typically, a clinical evaluation is sufficient to diagnose HFMD. Lab tests which may prove useful are:
- Virus isolation: Swabs taken from the vesicles, ulcers or stool can be utilized for isolating the virus. It can then be cultured on viral tissue media or inoculated into mice to obtain a larger sample for demonstration
- Serologic tests:
• Acute phase : Neutralizing antibodies can be detected;
• Convalescent phase - For retrospective diagnosis, complement-fixing antibodies can be detected
- PCR can be used to distinguish between coxsackie virus A16 and enterovirus 71(6). It has prognostic significance. The usefulness of this technique lies in the fact that epidemics caused by enterovirus 71 tend to be more severe and are associated with more complications and fatalities.


References
Hand, Foot and Mouth Disease Hand, Foot and Mouth Disease 01/12/2012
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