Typhoid (Enteric Fever)

Dr Ira Shah
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Typhoid (Enteric Fever) - Treatment
Due to multidrug resistance to chloramphenicol, ampicillin and TMP-SMX, 3rd generation cephalosporins and fluoroquinolones are drugs of choice.
Ciprofloxacin (10-15 mg/kg/d) for 7-10 days is effective and has a low recurrence rate.
Cefotaxime (200mg/kg/d) intravenously in 3-4 divided doses or ceftriaxone (100mg/kg/d IV in 1 or 2 divided doses) for 7-10 days have also been successful in treating enteric fever caused by resistant strains. Cefixime (8mg/kg/d PO in BD doses) for 7-10 days have also been successful.

Other antimicrobial agents useful are-
Chloramphenicol (50 mg/kg/d PO or 75 mg/kg/d IV in 4 equal doses) for at least 14 days.
Ampicillin (200mg/kg/d IV in 3-4 doses) for 14 days.
Amoxicillin (100mg/kg/d PO in 3 doses) for 14 days.
TMP- SMX (10mg of TMP/kg/d PO in 2 doses) for 14 days.
In children with malnutrition, antibiotic therapy can be extended for 21 days to reduce the rate of complications.


Typhoid (Enteric Fever) Typhoid (Enteric Fever) 02/05/2001
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