Drug Index

Dimenhydrinate

 
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Mechanism :

Dimenhydrinate is an antihistamine with anticholinergic and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells.


Indication :

• Motion sickness

• Radiation sickness

• Postoperative vomiting

• Drug induced nausea and vomiting

• Symptomatic relief of nausea and vertigo due to ménière disease and other labyrinthine disturbances


Contraindications :

Glaucoma, chronic lung disease, difficulty in urination due to prostatic hypertrophy.

Use with caution in patients with a history of seizure disorder.


Dosing :

IV/IM: 1.25 mg/kg or 37.5 mg/sqm every 6 hours. Max: 300 mg/day

Oral:

2 to 12 years: 12.5 to 25 mg every 6 to 8 hours as necessary to a maximum of 75 mg in 24 hours for children between 2-6 years and 150 mg/24 hours for those between 6-12 years.

>12 years: 50 mg every 4 to 6 hours as necessary to a maximum of 400 mg in 24 hours.


Adverse Effect :

Drowsiness, dizziness, dry mouth, lassitude, paradoxical CNS stimulation, rash, hemolytic anemia, blurring of vision.


Interaction :

Alcohol and other CNS depressants: Diphenhydramine hydrochloride has additive effects.

MAO inhibitors: prolong and intensify the anticholinergic effects of antihistamines.


07/19/2019 03:06:06 Dimenhydrinate
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