Drug Index


Mechanism :

Dimenhydrinate is an antihistamine with anticholinergic and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells.

Indication :

  • Motion sickness
  • Radiation sickness
  • Postoperative vomiting
  • Drug induced nausea and vomiting
  • Symptomatic relief of nausea and vertigo due to ménière disease and other labyrinthine disturbances

Contraindications :

Glaucoma, chronic lung disease, difficulty in urination due to prostatic hypertrophy.

Use with caution in patients with a history of seizure disorder.

Dosing :

1.25 mg/kg or 37.5 mg/m² every 6 hours. Max: 300 mg/day
2 to 12 years:
12.5 to 25 mg every 6 to 8 hours as necessary to a maximum of 75 mg in 24 hours for children between 2-6 years and 150 mg/24 hours for those between 6-12 years.
>12 years:
50 mg every 4 to 6 hours as necessary to a maximum of 400 mg in 24 hours.

Adverse Effect :

Drowsiness, dizziness, dry mouth, lassitude, paradoxical CNS stimulation, rash, hemolytic anemia, blurring of vision.

Interaction :

Alcohol and other CNS depressants: Diphenhydramine hydrochloride has additive effects.

MAO inhibitors: prolong and intensify the anticholinergic effects of antihistamines.

Hepatic Dose :

Dose reduction may be required as dimenhydrinate is eliminated primarily by hepatic metabolism.
01/20/2024 14:11:49 Dimenhydrinate
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