Drug Index

Promethazine

 
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Mechanism :

Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. Promethazine is an H1 receptor blocking agent. In addition to its antihistaminic action, it provides clinically useful sedative and antiemetic effects.


Indication :

• Sedation

• Antihistamine

• Nausea and vomiting

• Motion sickness


Contraindications :

Sensitivity to any of the components, patients receiving MAO inhibitors. Not recommended for children below 2 years of age.


Dosing :

<2 years, safety and efficacy not established.

>2 years: 0.25-1 mg/kg PO/PR every 4-6 hours as and when required; Maximum dose: 25 mg/day.


Adverse Effect :

Dryness of the mouth, blurring of vision, dizziness or mild stimulation and insomnia may occur. Rare: leukopenia.


Interaction :

Potentials sedative effects of other drugs; avoid alcohol.


07/18/2019 10:02:30 Promethazine
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