Drug Index


Mechanism :

Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. Promethazine is an H1 receptor blocking agent. In addition to its antihistaminic action, it provides clinically useful sedative and antiemetic effects.

Indication :

  • Sedation
  • Antihistamine
  • Nausea and vomiting
  • Motion sickness

Contraindications :

Sensitivity to any of the components, patients receiving MAO inhibitors. Not recommended for children below 2 years of age.

Dosing :

<2 years,
safety and efficacy not established.
>2 years:
0.25-1 mg/kg PO/PR every 4-6 hours as and when required; Maximum dose: 25 mg/day.

Adverse Effect :

Dryness of the mouth, blurring of vision, dizziness or mild stimulation and insomnia may occur. Rare: leukopenia.

Interaction :

Potentials sedative effects of other drugs; avoid alcohol.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Use in hepatic impairment is contraindicated as side effects of drug and CNS signs and symptoms of liver disease may be indistinguishable.
01/18/2024 19:51:06 Promethazine
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